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Article Publish Status: FREE
Abstract Title:

Novelextract containingβ-glucogallinmetformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia.

Abstract Source:

Food Funct. 2022 Sep 22 ;13(18):9523-9531. Epub 2022 Sep 22. PMID: 35996967

Abstract Author(s):

Muhammed Majeed, Lakshmi Mundkur, Shaji Paulose, Kalyanam Nagabhushanam

Article Affiliation:

Muhammed Majeed

Abstract:

The efficacy ofextract (EOE) containing 10%β-glucogallin was compared against metformin in newly diagnosed subjects with diabetic dyslipidemia which is a significant factor in cardiovascular disease. Daily administration with EOE-1 g, EOE-2 g, or metformin 500 mg for 90 days significantly decreased fasting blood sugar and postprandial blood sugar (FBS and PPBS), hemoglobin A1c (HbA1c) and lipid levels in all three treatment groups. The FBS, PPBS and HbA1c were significantly lower in the EOE-2 g group compared with metformin and EOE-1 g groups. The reductions in LDL and TC in the EOE-2 g group were also significantly higher than in the EOE-1 g group and were comparable to the metformin group. No serious adverse effects were observed in any study participants. EOE-1 g and 2 g dayare safe and potent antidiabetic agents, with comparable efficacy to the pharmaceutical drug, metformin. Supplementation with EOE-2 g dayshowed greater efficacy than metformin in reducing circulating glucose levels.

Study Type : Human Study

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