Novel fatty acid in Cordyceps suppresses influenza A virus-induced proinflammatory response. - GreenMedInfo Summary
Novel Fatty Acid inSuppresses Influenza A (H1N1) Virus-Induced Proinflammatory Response Through Regulating Innate Signaling Pathways.
ACS Omega. 2021 Jan 19 ;6(2):1505-1515. Epub 2021 Jan 7. PMID: 33490810
Run-Feng Li
Influenza virus (IV) infections usually cause acute lung injury characterized by exaggerated proinflammatory responses. The paucity of therapeutic strategies that target host immune response to attenuate lung injury poses a substantial challenge in management of IV infections. In this study, we chemically synthesized a novel fatty acid (2,4)-deca-2,4-dienoic acid (DDEA) identified fromby using UHPLC-Q-TOF-MS techniques. The DDEA did not inhibit H1N1 virus replication but attenuated proinflammatory responses by reducing mRNA and protein levels of TNF-α, IFN-α, IFN-β, IL-6, CXCL-8/IL-8, CCL-2/MCP-1, CXCL-10/IP-10, CCL-3/MIP-1α, and CCL-4/MIP-1β in A549 cells and U937-derived macrophages. The anti-inflammatory effect occurred through downregulations of TLR-3-, RIG-I-, and type I IFN-activated innate immune signaling pathways. Altogether, ourresults indicate that DDEA may potentially be used as an anti-inflammatory therapy for the treatment of IV infections.