n/a
Article Publish Status: FREE
Abstract Title:

Novel Fatty Acid inSuppresses Influenza A (H1N1) Virus-Induced Proinflammatory Response Through Regulating Innate Signaling Pathways.

Abstract Source:

ACS Omega. 2021 Jan 19 ;6(2):1505-1515. Epub 2021 Jan 7. PMID: 33490810

Abstract Author(s):

Run-Feng Li, Xiao-Bo Zhou, Hong-Xia Zhou, Zi-Feng Yang, Hai-Ming Jiang, Xiao Wu, Wen-Jia Li, Jian-Jian Qiu, Jia-Ning Mi, Ming Chen, Nan-Shan Zhong, Guo-Yuan Zhu, Zhi-Hong Jiang

Article Affiliation:

Run-Feng Li

Abstract:

Influenza virus (IV) infections usually cause acute lung injury characterized by exaggerated proinflammatory responses. The paucity of therapeutic strategies that target host immune response to attenuate lung injury poses a substantial challenge in management of IV infections. In this study, we chemically synthesized a novel fatty acid (2,4)-deca-2,4-dienoic acid (DDEA) identified fromby using UHPLC-Q-TOF-MS techniques. The DDEA did not inhibit H1N1 virus replication but attenuated proinflammatory responses by reducing mRNA and protein levels of TNF-α, IFN-α, IFN-β, IL-6, CXCL-8/IL-8, CCL-2/MCP-1, CXCL-10/IP-10, CCL-3/MIP-1α, and CCL-4/MIP-1β in A549 cells and U937-derived macrophages. The anti-inflammatory effect occurred through downregulations of TLR-3-, RIG-I-, and type I IFN-activated innate immune signaling pathways. Altogether, ourresults indicate that DDEA may potentially be used as an anti-inflammatory therapy for the treatment of IV infections.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.