Abstract Title:

Novel strategy in breast cancer therapy: Revealing the bright side of ginsenosides.

Abstract Source:

Curr Mol Pharmacol. 2021 Jan 20. Epub 2021 Jan 20. PMID: 33494691

Abstract Author(s):

Farid Hashemi, Ali Zarrabi, Amirhossein Zabolian, Hossein Saleki, Mahdi Vasheghani Farahani, Seyed Omid Sharifzadeh, Zahra Ghahremaniyeh, Atefe Kazemzade Bejandi, Kiavash Hushmandi, Milad Ashrafizadeh, Haroon Khan

Article Affiliation:

Farid Hashemi


Breast cancer is one of the leading causes of death worldwide. Breast cancer cells demonstrate uncontrolled proliferation, and high metastatic capacity. They can obtain resistance to chemotherapy and radiotherapy. This has resulted in troublesome problems in its treatment. Nature as a rich source of plant derived-natural products with anti-tumor activity can be of interest in breast cancer therapy. Ginsenosides are triterpenoid saponins and considered as secondary metabolites exclusively found in Panax species. From immemorial times, ginsenosides have been applied in treatment of various disorders such as diabetes, inflammatory diseases, neurological disorders, and particularly, cancer. In the present review, we highlight anti-tumor activity of ginsenosides against breast cancer cells. Ginsenosides are able to induce apoptosis and cell cycle arrest. They interfere with breast cancer metastasis via inhibiting epithelial-to-mesenchymal transition, matrix metalloproteinase proteins and angiogenesis. Ginsenosides can promote efficacy of chemotherapy via suppressing migration and proliferation. Molecular pathways such as phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), insulin-like growth factor-1, Wnt, microRNAs and long non-coding RNAs are affected by ginsenosides in suppressing breast cancer malignancy. Consequently, ginsenosides are versatile compounds in breast cancer therapy by suppressing growth, and invasion, as well as promoting their sensitivity to chemotherapy.

Study Type : In Vitro Study

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