Abstract Title:

Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality.

Abstract Source:

Aging (Albany NY). 2020 Jun 2 ;12. Epub 2020 Jun 2. PMID: 32487780

Abstract Author(s):

Dai Zhang, Cong Dai, Linghui Zhou, Yiche Li, Kang Liu, Yu-Jiao Deng, Na Li, Yi Zheng, Qian Hao, Si Yang, Dingli Song, Ying Wu, Zhen Zhai, Shiyi Cao, Zhijun Dai

Article Affiliation:

Dai Zhang


Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks and 95% confidence intervals were calculated using random-effects and fixed-effects models. We included 38 studies on nut consumption and cancer risk and 9 studies on cancer-specific mortality. Compared with no nut intake, nut intake was associated with a lower cancer risk (Relative Risk=0.90; 95% confidence interval, 0.86-0.94). Inverse associations were observed with colorectal cancer, gastric cancer, pancreatic cancer, and lung cancer in subgroup analyses. Tree nut consumption was found to reduce cancer risk (Relative Risk=0.88; 95% confidence interval, 0.79-0.99). Dose-response curves suggested that protective benefits against cancer increased with increased nut intake (P=0.005, P-nonlinearity=0.0414). An inverse correlation with cancer-specific mortality (Odd Ratio=0.90; 95% confidence interval, 0.88-0.92) was observed. In conclusion, nut consumption is inversely associated with the risks of cancer incidence and mortality; a higher intake is significantly associated with a lower cancer risk.

Study Type : Meta Analysis

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