Article Publish Status: FREE
Abstract Title:

Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.

Abstract Source:

Diabetes Care. 2013 Jun ;36(6):1454-61. Epub 2012 Dec 28. PMID: 23275372

Abstract Author(s):

Marie Hokayem, Emilie Blond, Hubert Vidal, Karen Lambert, Emmanuelle Meugnier, Christine Feillet-Coudray, Charles Coudray, Sandra Pesenti, Cedric Luyton, Stéphanie Lambert-Porcheron, Valerie Sauvinet, Christine Fedou, Jean-Frédéric Brun, Jennifer Rieusset, Catherine Bisbal, Ariane Sultan, Jacques Mercier, Joelle Goudable, Anne-Marie Dupuy, Jean-Paul Cristol, Martine Laville, Antoine Avignon

Article Affiliation:

Marie Hokayem


OBJECTIVE: To assess the clinical efficacy of nutritional amounts of grape polyphenols (PPs) in counteracting the metabolic alterations of high-fructose diet, including oxidative stress and insulin resistance (IR), in healthy volunteers with high metabolic risk.

RESEARCH DESIGN AND METHODS: Thirty-eight healthy overweight/obese first-degree relatives of type 2 diabetic patients (18 men and 20 women) were randomized in a double-blind controlled trial between a grape PP (2 g/day) and a placebo (PCB) group. Subjects were investigated at baseline and after 8 and 9 weeks of supplementation, the last 6 days of which they all received 3 g/kg fat-free mass/day of fructose. The primary end point was the protective effect of grape PPs on fructose-induced IR.

RESULTS: In the PCB group, fructose induced 1) a 20% decrease in hepatic insulin sensitivity index (P<0.05) and an 11% decrease in glucose infusion rate (P<0.05) as evaluated during a two-step hyperinsulinemic-euglycemic clamp, 2) an increase in systemic (urinary F2-isoprostanes) and muscle (thiobarbituric acid-reactive substances and protein carbonylation) oxidative stress (P<0.05), and 3) a downregulation of mitochondrial genes and decreased mitochondrial respiration (P<0.05). All the deleterious effects of fructose were fully blunted by grape PP supplementation. Antioxidative defenses, inflammatory markers, and main adipokines were affected neither by fructose nor by grape PPs.

CONCLUSIONS: A natural mixture of grape PPs at nutritional doses efficiently prevents fructose-induced oxidative stress and IR. The current interest in grape PP ingredients and products by the global food and nutrition industries could well make them a stepping-stone of preventive nutrition.

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