Abstract Title:

Effects of dietary oat proteins on cholesterol metabolism of hypercholesterolaemic hamsters.

Abstract Source:

J Sci Food Agric. 2016 Mar 15 ;96(4):1396-401. Epub 2015 May 21. PMID: 25913820

Abstract Author(s):

Li-Tao Tong, Lina Guo, Xianrong Zhou, Ju Qiu, Liya Liu, Kui Zhong, Sumei Zhou

Article Affiliation:

Li-Tao Tong


BACKGROUND: The aim of present study was to investigate the hypocholesterolaemic effects of oat proteins (OP) in hamsters fed with a hypercholesterolaemic diet. The hamsters were divided into five groups and fed with the experimental diets containing oat, OP, oatβ-glucan (OG), or OP+OG for 30 days.

RESULTS: OP and the OG significantly lowered the concentrations of plasma low-density lipoprotein-cholesterol and liver total cholesterol (TC), and increased the excretion of faecal bile acid and TC. Plasma and liver TC in the OP+OG group were significantly lower than those in the OP or OG groups. Both OP and OG increased the activity of liver cholesterol 7α-hydroxylase (CYP7A1), while its activity in the OP+OG group was strongly increased compared with the OP or OG groups.

CONCLUSION: These results indicated that dietary OP could improve hypercholesterolaemia, while dietary OP and OG together would have better hypocholesterolaemic effects.

Study Type : Animal Study

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Sayer Ji
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