Abstract Title:

The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans.

Abstract Source:

Clin Endocrinol (Oxf). 2006 May;64(5):523-9. PMID: 16649971

Abstract Author(s):

Lisa B Yanoff, Shamik J Parikh, Amanda Spitalnik, Blakeley Denkinger, Nancy G Sebring, Pamela Slaughter, Theresa McHugh, Alan T Remaley, Jack A Yanovski

Article Affiliation:

Unit on Growth and Obesity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1103, USA.


CONTEXT: Both obesity (body mass index, BMI>or = 30 kg/m2) and Black race are associated with a higher risk of vitamin D deficiency and secondary hyperparathyroidism. We hypothesized the risk of hypovitaminosis D would therefore be extraordinarily high in obese Black adults. OBJECTIVE: To study the effects of race and adiposity on 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (iPTH). DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study of 379 Black and White adults from the Washington D.C. area. BMI ranged from 19.9 to 58.2 kg/m2. MAIN OUTCOME MEASURES: Prevalence of hypovitaminosis D [25(OH)D<37.5 nmol/l] and secondary hyperparathyroidism [25(OH)D<37.5 nmol/l with iPTH>4.2 pmol/l]. RESULTS: Obese Black subjects had lower mean 25(OH)D, 40.3 (SD, 20.3) nmol/l, compared with obese Whites, 64.5 (29.7), P<0.001, nonobese Blacks, 53.3 (26.0), P = 0.0025 and nonobese Whites, 78.0 (33.5), P<0.001. The prevalence of hypovitaminosis D increased with increasing BMI, and was greater (P<0.001) in Blacks than Whites within all BMI categories examined. Among subjects with BMI>or = 35 kg/m2, 59% of Blacks vs 18% of Whites had hypovitaminosis D (odds ratio 6.5, 95% confidence interval 3.0-14.2). iPTH was negatively correlated with 25(OH)D (r = -0.31, P<0.0001), suggesting those with hypovitaminosis D had clinically important vitamin D deficiency with secondary hyperparathyroidism. For secondary hyperparathyroidism 35.2% of Blacks met the criteria, compared to 9.7% of Whites (OR 3.6, CI 1.5-98.8). CONCLUSIONS: Obese Black Americans are at particularly high risk for vitamin D deficiency and secondary hyperparathyroidism. Physicians should consider routinely supplementing such patients with vitamin D or screening them for hypovitaminosis D.

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