Abstract Title:

[Effects of eight environmental endocrine disruptors on insulin resistance in patients with polycystic ovary syndrome: a preliminary investigation].

Abstract Source:

Nan Fang Yi Ke Da Xue Xue Bao. 2011 Oct ;31(10):1753-6. PMID: 22027783

Abstract Author(s):

Ting-Ting Li, Liang-Zhi Xu, Yong-Heng Chen, Hong-Mei Deng, Chun-Ying Liang, Ying Liu, Xiao-Fang Liu, Jing Zhang, De-Ying Kang, Dong-Sheng Qiu, Dai-Wen Han, Rong Hu

Article Affiliation:

Department of Obstetrics and Gynecology, West China Second University Hospital, West China Hospital, Sichuan University, Chengdu 610041, China. E-mail: [email protected]


OBJECTIVE: To investigate the relationship between 8 endocrine-disrupting chemicals in the serum and insulin resistance in patients with polycystic ovary syndrome (PCOS).

METHODS: This study was conducted among 60 patients with PCOS, including 23 with insulin resistance (PCOS-IR) and 37 without insulin resistance (PCOS-NIR), and 29 non-PCOS women seeking medical attention for infertility or menstrual disorder (control group). The serum levels of 6 phthalic acid esters (PEAs), bisphenol A (BPA) and octylphenol (OP) were measured in all the subjects.

RESULTS: The levels of PAEs, BPA and OP showed no significant differences between PCOS patients and the control group (P>0.05). The serum level of OP was significantly lower in patients PCOS-IR than in those with PCOS-NIR (47.89 ng/ml vs 60.24 ng/ml, P<0.05).

CONCLUSION: PEAs and BPA do not produce obvious effect on the pathogenesis of PCOS or contribute to insulin resistance, but OP may play a role in insulin resistance in PCOS patients.

Study Type : Human Study

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Sayer Ji
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