Abstract Title:

Oleuropein Induces Anti-metastatic Effects in Breast Cancer.

Abstract Source:

Asian Pac J Cancer Prev. 2012 ;13(9):4555-9. PMID: 23167379

Abstract Author(s):

Zeinab K Hassan, Maha H Elamin, Maha H Daghestani, Sawsan A Omer, Ebtesam M Al-Olayan, Mai A Elobeid, Promy Virk, Osama B Mohammed

Article Affiliation:

Department of Zoology, College of Science, King Saud University, University Centre for Women Students, Riyadh, Saudi Arabia E-mail : [email protected]


Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase (MMP) enzymes which facilitate invasion. Oleuropein, the main olive oil polyphenol, has anti-proliferative effects. This study aimed to investigate the effect of oleuropein on the metastatic and anti-metastatic gene expression in the MDA human breast cancer cell line. We evaluated the MMPs and TIMPs gene expression by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in treated and untreated cells. This study demonstrated that OL may induce anti-metastatic effects on human breast cancer cells. We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially. Treatment of breast cancer cells with oleuropein could help in prevention of cancer metastasis by increasing the TIMPs and suppressing the MMPs gene expressions.

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