Abstract Title:

In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1).

Abstract Source:

Sci Pharm. 2011 Sep ;79(3):615-621. Epub 2011 Jun 9. PMID: 21886907

Abstract Author(s):

Eamon P Rafferty, Alastair R Wylie, Chris T Elliott, Olivier P Chevallier, David J Grieve, Brian D Green

Article Affiliation:

School of Biological Sciences, Queen's University Belfast, BT9 5AG, Northern Ireland, United Kingdom.


Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P<0.05-0.001). Oral gavage of OLE and GLN modestly increased plasma GLP-1 concentrations (48% and 41%, respectively), but did not lower glycaemic excursions. OLE and GLN are potent stimulators of GLP-1 secretion both in vitro and in vivo and chronic studies should assess their suitability as nutritional therapies for type 2 diabetes.

Study Type : Animal Study

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