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Abstract Title:

Effects of Omega-3 Fatty Acid Supplementation on Inflammatory Cytokines and Advanced Glycation End Products in Patients With Diabetic Nephropathy: a Randomized Controlled Trial.

Abstract Source:

Iran J Kidney Dis. 2016 Jul ;10(4):197-204. PMID: 27514766

Abstract Author(s):

Seyyed Mehdi Mirhashemi, Faeze Rahimi, Alireza Soleimani, Zatollah Asemi

Article Affiliation:

Seyyed Mehdi Mirhashemi

Abstract:

INTRODUCTION: This study was performed to evaluate the effects of omega-3 fatty acid supplementation on inflammatory cytokines and advanced glycation end products (AGEs) in patients with diabetic nephropathy (DN).

MATERIALS AND METHODS: This randomized double-blind placebo-controlled trial was done on 60 patients with DN who were randomly divided into 2 groups to receive either 1000 mg/d of omega-3 fatty acid from flaxseed oil (n = 30) or placebo (n = 30) for 12 weeks. The primary outcome variables were tumor necrosis factor-α, receptor tumor necrosis factor-αand growth differentiation factor 15. Fasting blood samples were taken at the onset and the end of the study to quantify the related markers.

RESULTS: Compared with the placebo, omega-3 fatty acid supplementation resulted in a significant decrease in serum AGEs (-2.3±2.8 AU versus 0.2±2.5 AU, P = .001). Despite a significant reduction in serum level of receptor for AGEs (-0.1±0.3 AU, P = .02) in the omega-3 fatty acid group, no significant difference was found between the two groups in terms of their effects on the receptor for AGEs. Supplementation with omega-3 fatty acid had no significant effect on the inflammatory cytokines as compared with the placebo.

CONCLUSIONS: Our study demonstrated that omega-3 fatty acid supplementation among DN patients had favorable effects on AGEs and the receptor for AGEs.

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