Abstract Title:

Omega-3 polyunsaturated Fatty Acid supplementation reduced atrial fibrillation recurrence after pulmonary vein antrum isolation.

Abstract Source:

J Invest Dermatol. 1989 Jun;92(6):842-7. PMID: 19898653

Abstract Author(s):

Dimpi Patel, Mazen Shaheen, Preeti Venkatraman, Luciana Armaganijan, Javier E Sanchez, Rodney P Horton, Luigi Di Biase, Prasant Mohanty, Robert Canby, Shane M Bailey, J David Burkhardt, G Joseph Gallinghouse, Jason D Zagrodzky, Marketa Kozeluhova, Andrea Natale


OBJECTIVE: To assess if patients treated with omega-3(n-3) polyunsaturated fatty acids (PUFAS) had lower procedural failure rates compared to an untreated population. METHODS AND RESULTS: From January 2004 to 2007, 1500 PVAI patients underwent catheter ablation. Two hundred and eighty five (19%) patients were treated with PUFAs. These patients were matched in a nested case controlled analysis. After matching, there were 129 patients in the PUFA group and 129 in the control group. Thirty-five (27.1%) patients in the study group had early recurrence vs. 57 (44.1%) in the control group p-value< 0.0001. Twenty-nine (23.2%) patients in the PUFA group vs. 41 (31.7%) in the non-PUFA group had procedural failure (p-value < 0.003). There were no significant differences in complications in the PUFA and non-PUFA groups. CONCLUSION: Patients treated with PUFAs had lower incidences of early recurrence and procedural failure compared to an untreated population.

Study Type : Human Study

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Sayer Ji
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