Article Publish Status: FREE
Abstract Title:

Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B₄ and leukotriene B₅ production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial.

Abstract Source:

Nutrients. 2014 Sep 29 ;6(10):4043-57. Epub 2014 Sep 29. PMID: 25268838

Abstract Author(s):

Lone S Sorensen, Ole Thorlacius-Ussing, Henrik H Rasmussen, Søren Lundbye-Christensen, Philip C Calder, Karen Lindorff-Larsen, Erik B Schmidt

Article Affiliation:

Lone S Sorensen


Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-3 FA-enriched oral nutritional supplement (ONS) providing 2.0 g of eicosapentaenoic acid (EPA) and 1.0 g of docosahexaenoic acid (DHA) per day or a standard ONS for seven days before surgery. On the day of operation, there was a significant increase in the production of leukotriene B5 (LTB5) (p<0.01) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p<0.01), a significant decrease in the production of leukotriene B4 (LTB4) (p<0.01) and a trend for a decrease in the production of 5-hydroxyeicosatetraenoic acid (5-HETE) (p<0.1) from stimulated neutrophils in the active group compared with controls. There was no association between LTB4 values and postoperative complications. In conclusion, oral n-3 FA exerts anti-inflammatory effects in surgical patients, without reducing the risk of postoperative complications.

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