Abstract Title:


Abstract Source:

Int Ophthalmol Clin. 1975;15(4):229-41. PMID: 773881

Abstract Author(s):

V Boniuk


Experience with the vaccine can be summarized as follows: There were minimal problems with neuralgia and neuropathy as a result of the vaccine; vaccinated children were not a significant source of infection to the pregnant woman; the duration of immunity is similar to that obtained with natural rubella virus, but with lower antibody levels; and reinfection is more common with vaccination, but apparently no viremia develops. Several studies were reported regarding inadvertent vaccination in women who were pregnant at the time of vaccination. In one series [7], 19 pregnant women who were vaccinated were studied. Ten went to term and delivered normal babies and 9 aborted, 8 induced and 1 spontaneously. In one induced abortion, virus was demonstrable in fetal tissue including, notably, in the eye. Another case of CRS was diagnosed in utero amniocentesis [12], and the fetus was aborted at 12 weeks' gestation. Another evaluation of reinfection during pregnancy [1] confirmed that this was of little risk to the fetus, as there was no apparent viremia. In summary, then, in one ophthalmological generation, from Gregg until the present time, we have experienced the recognition, the observation, and, essentially, the conquest of the congenital rubella syndrome. However, if vaccination programs are not assiduously continued, we can expect a renewed upsurge of this difficult problem.

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Sayer Ji
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