Abstract Title:

Optic neuritis after anthrax vaccination.

Abstract Source:

Ophthalmology. 2002 Jan ;109(1):99-104. PMID: 11772587

Abstract Author(s):

John B Kerrison, David Lounsbury, Charles E Thirkill, R Gary Lane, Martha P Schatz, Renata M Engler

Article Affiliation:

John B Kerrison


OBJECTIVE: To report the occurrence of optic neuritis after anthrax vaccination in two patients.

DESIGN: Observational case reports, review of literature.

METHODS: Description of clinical history, examination, neuroimaging, and further studies in two patients experiencing optic neuritis in temporal association with anthrax vaccination.

MAIN OUTCOME MEASURES: Visual acuity, visual fields.

RESULTS: Two patients, 39 and 23 years of age, were seen with acute optic neuritis 1 month and 2 weeks, respectively, after anthrax booster vaccination and successfully treated with intravenous methylprednisolone. The first patient had a typical presentation and course of unilateral retrobulbar optic neuritis with excellent visual recovery. The second patient had a bilateral anterior optic neuritis and has required chronic immunosuppression to maintain his vision. Retinal and optic nerve autoantibodies were present in the second patient. No cross-reactive epitopes between anthrax vaccine and retina/optic nerve were identified.

CONCLUSION: Optic neuritis is a potential adverse reaction of anthrax vaccination.

Study Type : Human: Case Report

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Sayer Ji
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