Abstract Title:

Oral activated charcoal in patients with uremic pruritus.

Abstract Source:

Nephron. 1995 ;70(2):193-6. PMID: 7566302

Abstract Author(s):

S Giovannetti, G Barsotti, A Cupisti, L Dani, S Bandini, D Angelini, A Antonelli, M Salvadori, D A Urti

Article Affiliation:

S Giovannetti


Twenty-three chronic uremic patients on maintenance hemodialysis and suffering from severe pruritus were treated with activated powdered charcoal (6 g daily p.o.). In 10 patients pruritus disappeared completely, and in 10 other patients a partial effect was observed. The favorable results persisted for several weeks after discontinuation of the treatment. Only 3 cases were totally unresponsive. No relevant undesirable side effects were observed with the exception of 1 case who showed treatment intolerance. It is concluded that activated charcoal per os is a safe, effective, and low-cost therapy for patients with uremic pruritus, but its mechanism of action is unknown.

Study Type : Human Study

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