Article Publish Status: FREE
Abstract Title:

Oral Administration of ProbioticImproves Facilitation of Hippocampal Memory Extinction via Restoration of Aberrant Higher Induction of Neuropsin in an MPTP-Induced Mouse Model of Parkinson's Disease.

Abstract Source:

Biomedicines. 2021 Feb 8 ;9(2). Epub 2021 Feb 8. PMID: 33567772

Abstract Author(s):

Toshiaki Ishii, Hidefumi Furuoka, Motohiro Kaya, Tetsuya Kuhara

Article Affiliation:

Toshiaki Ishii


We previously reported that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease (PD) model mice (PD mice) facilitate hippocampal memory extinction, which may be the cause of cognitive impairment in PD. Recent studies on the consumption of probiotics have reported a variety of beneficial effects on the central nervous system via the microbiota-gut-brain axis. In this study, we investigated the effects of oral administration ofstrain A1 [MCC1274] (A1) on the facilitation of hippocampal memory extinction observed in PD mice. We found that four-day consecutive oral administration ofA1 restored facilitation of contextual fear extinction in PD mice. Hippocampal mRNA expression levels of postsynaptic density protein-95 and synaptophysin significantly decreased in the PD mice, but mRNA and protein expression levels of neuropsin increased. Furthermore, CA1 apical spine density was significantly reduced in PD mice. On the other hand, administration ofA1 to PD mice recovered all these expression levels and the CA1 spine density to control levels. These results suggest that increased induction of neuropsin is involved in abnormal changes in hippocampal synaptic plasticity, and thatA1 imposes reins on its expression, resulting in the restoration of abnormal hippocampal synaptic plasticity and the facilitation of fear extinction in PD mice.

Study Type : Animal Study

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