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Article Publish Status: FREE
Abstract Title:

Oral Administration ofPrevents UVB-Induced Skin Aging through Targeting the c-Raf Signaling Axis.

Abstract Source:

Antioxidants (Basel). 2021 Oct 22 ;10(11). Epub 2021 Oct 22. PMID: 34829534

Abstract Author(s):

Seongin Jo, Young-Sung Jung, Ye-Ryeong Cho, Ji-Won Seo, Won-Chul Lim, Tae-Gyu Nam, Tae-Gyu Lim, Sanguine Byun

Article Affiliation:

Seongin Jo

Abstract:

is a widely used Rosa species for medicinal and culinary purposes.has been reported to display antioxidant, anti-inflammatory, and antibacterial activities. However, the effect ofagainst skin aging in vivo is unknown and its active components have not been fully understood. Oral administration ofprevented UVB-mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed thatdownregulates UVB-induced COX-2 and MMP-1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC-MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by. Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c-Raf/MEK/ERK/c-Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB-induced MMP-1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively,could be used as a functional ingredient in the development of nutraceuticals against skin aging.

Study Type : Animal Study

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