Article Publish Status: FREE
Abstract Title:

Oral Administration of Zataria multiflora Extract Decreases IL-17 Expression in Perennial Allergic Rhinitis.

Abstract Source:

Rep Biochem Mol Biol. 2018 Apr ;6(2):203-207. PMID: 29766004

Abstract Author(s):

Nazila Ariaee, Jalal Ghorbani, Maryam Panahi, Mojgan Mohamadi, Javad Asili, Alireza Ranjbar, Reza Farid Hoseini, Farahzad Jabbari

Article Affiliation:

Nazila Ariaee


Background: Rhinitis, which occurs most commonly as allergic rhinitis and affects 20% of the world's population, is a major health care burden causing significant morbidity. Considering the high prevalence of allergic rhinitis and anti-inflammatory effects of thyme, a favorite condiment, we performed a randomized clinical trial to determine whether thyme can relieve allergic rhinitis symptoms and affect the expression of TH17- and T-regulatory cell- (Treg) related cytokines IL-17, TGF-β, FOXP3, and IL-10.

Methods: Thirty patients with allergic rhinitis symptoms and positive skin prick test for common aero allergens were randomly assigned to experimental or control groups. The experimental group received thyme or(ZM) extracts and the control group received placebo for two months. Expression of IL-17, TGF-β, FOXP3, and IL-10 was evaluated in all subjects by real-time PCR before and after intervention.

Results: After treatment IL-17 expression was significantly less in the ZM group than in controls (p<0.05), while TGF-β, FOXP3, and IL-10, expression were not significantly changed.

Conclusion: Given the significant effect of thyme in reducing symptoms of allergic rhinitis and decrease IL-17 gene expression and because allergic rhinitis is a multifactorial disease, the administration of thyme extract along with conventional treatments may benefit allergic rhinitis sufferers.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.