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Article Publish Status: FREE
Abstract Title:

Oral exposure to bisphenols induced food intolerance and colitis in vivo by modulating immune response in adult mice.

Abstract Source:

Food Chem Toxicol. 2020 Dec ;146:111773. Epub 2020 Oct 1. PMID: 33011352

Abstract Author(s):

Yann Malaisé, Corinne Lencina, Fanny Placide, Valérie Bacquié, Christel Cartier, Maïwenn Olier, Manuela Buettner, Markus Wallbrecht, Sandrine Ménard, Laurence Guzylack-Piriou

Article Affiliation:

Yann Malaisé

Abstract:

Bisphenol (BP) A, a known food contaminant, is a possible risk factor in the epidemic of non-communicable diseases (NCD) including food intolerance and inflammatory bowel diseases (IBD). Regulatory restrictions regarding BPA usage led to BPA removal and replacement by poorly described substitutes, like BPS or BPF (few data on occurrence in food and human samples and biological effect). Oral tolerance protocol to ovalbumin (OVA) in WT mice and Il10mice prone to IBD were used respectively to address immune responses towards food and microbial luminal antigens following BP oral exposure. Both mice models were orally exposed for five weeks to BPA, BPS or BPF at 0.5, 5 and 50 μg/kg of body weight (bw)/day (d). Oral exposure to BPs at low doses (0.5 and 5 μg/kg bw/d) impaired oral tolerance as indicated by higher humoral and pro-inflammatory cellular responses in OVA-tolerized mice. However, only BPF exacerbate colitis in Il10prone mice associated with a defect of fecal IgA and increased secretion of TNF-α in colon. These findings provide a unique comparative study on effects of adult oral exposure to BPs on immune responses and its consequences on NCD related to intestinal luminal antigen development.

Study Type : Animal Study

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