Abstract Title:

Orange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthy adult women.

Abstract Source:

J Am Coll Nutr. 2003 Dec ;22(6):519-23. PMID: 14684757

Abstract Author(s):

Carol S Johnston, Candice L Dancho, Gail M Strong

Article Affiliation:

Carol S Johnston


OBJECTIVE: To directly examine the contribution of vitamin C to the antioxidant potential of fruits and vegetables, the antioxidant effect of orange juice consumption (8 and 16 fl. oz.) was compared to the antioxidant effect of supplemental vitamin C (dosage equivalent to that supplied by 8 fl. oz. of orange juice).

METHODS: Subjects (n = 11; 28.6 +/- 2.1 years) received each treatment in a 3 x 3 randomized crossover design, and each two-week treatment was preceded by a two-week washout. During the entire trial, subjects restricted fruit and vegetable consumption to20 mg/serving), which were restricted to

RESULTS: Following washouts, plasma vitamin C and lipid peroxidation (plasma TBARS) were similar by treatment group and averaged 25.4 +/- 3.6 micromol/L and 3.82 +/- 0.10 nmol/mL respectively. Plasma vitamin C concentrations were similar following each treatment period, 37.9 +/- 8.1, 45.8 +/- 9.4, and 38.3 +/- 12.4 micromol/L for the 8 and 16 fl. oz. orange juice treatments and the supplement treatment, respectively. All intervention treatments reduced plasma TBARS as compared to pretreatment values: -47% (p = 0.013), -40% (p = 0.083), and -46% (p = 0.015) for the 8 and 16 fl. oz. orange juice treatments and supplement treatment respectively.

CONCLUSIONS: These data indicate that the regular consumption of 8 fl. oz. orange juice or supplemental vitamin C ( approximately 70 mg/day) effectively reduced a marker of lipid peroxidation in plasma.

Study Type : Human Study

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