Article Publish Status: FREE
Abstract Title:

Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria.

Abstract Source:

Rev Soc Bras Med Trop. 2019 Jun 27 ;52:e20180502. Epub 2019 Jun 27. PMID: 31271619

Abstract Author(s):

Nathalie Gaebler Vasconcelos, Júlio Croda, Késia Esther Silva, Maria Lorenza Leal Motta, Wirlaine Glauce Maciel, Letícia Cristina Limiere, Simone Simionatto

Article Affiliation:

Nathalie Gaebler Vasconcelos


INTRODUCTION: Plant products are sources for drug development against multidrug resistant bacteria.

METHODS: The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays.

RESULTS: Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment.

CONCLUSIONS: OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.

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