Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19. - GreenMedInfo Summary
Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19.
Microbes Infect. 2020 10 ;22(9):405-406. Epub 2020 Jun 24. PMID: 32590062
Jeremia M Coish
Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.