Abstract Title:

Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus.

Abstract Source:

Science. 2002 Apr 12 ;296(5566):356-9. Epub 2002 Mar 14. PMID: 11896235

Abstract Author(s):

Olen Kew, Victoria Morris-Glasgow, Mauricio Landaverde, Cara Burns, Jing Shaw, Zacarías Garib, Jean André, Elizabeth Blackman, C Jason Freeman, Jaume Jorba, Roland Sutter, Gina Tambini, Linda Venczel, Cristina Pedreira, Fernando Laender, Hiroyuki Shimizu, Tetsuo Yoneyama, Tatsuo Miyamura, Harrie van Der Avoort, M Steven Oberste, David Kilpatrick, Stephen Cochi, Mark Pallansch, Ciro de Quadros

Article Affiliation:

Olen Kew


An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.

Study Type : Human Study
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