Article Publish Status: FREE
Abstract Title:

-coumaric acid, an active ingredient of, ameliolates atopic dermatitis-like skin lesions through inhibition of thymic stromal lymphopoietin in mice.

Abstract Source:

J Ginseng Res. 2021 Jan ;45(1):176-182. Epub 2020 Jul 5. PMID: 33437169

Abstract Author(s):

Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Hyung-Min Kim, Hyun-Ja Jeong

Article Affiliation:

Phil-Dong Moon


Background: Atopic dermatitis (AD) is associated with chronic skin inflammatory reactions.-coumaric acid (CA) is an active ingredient ofMeyer (Araliaceae).

Methods: Here, we estimated an anti-AD effect ofCA on activated mast cells, activated splenocytes, and a mouse model of AD. Cytokines levels were measured by ELISA and protein activation was analyzed by Western blotting. 2,4-dinitrofluorobenzene (DNFB) was used to induce AD-like skin lesions.

Results: The treatment withCA suppressed the productions and mRNA expressions of thymic stromal lymphopoietin (TSLP), TNF-ɑ, IL-6, and IL-1β in HMC-1 cells.CA downregulated the expressions of RIP2 and caspase-1, phosphorylated-(p)p38/pJNK/pERK, and pIKKβ/pIkBɑ/NF-κB in HMC-1 cells.CA also decreased the productions of TSLP, TNF-ɑ, IL-6, IL-4, and IFN-γ in the supernatant of stimulated splenic cells. Comparing to DNFB-sensitized control group,CA-treated group alleviated pathological changes of AD-like lesions.CA decreased the proteins and mRNA expressions levels of TSLP, IL-6, and IL-4 in the skin lesions. Caspase-1 activation was also downregulated byCA treatment in the AD-like lesions. The serum levels of histamine, IgE, TSLP, TNF-ɑ, IL-6, and IL-4 were suppressed following treatment withCA.

Conclusion: This study suggests thatCA has the potential to improve AD by suppressing TSLP as well as inflammatory cytokines via blocking of caspase-1/NF-κB signal cascade.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.