Article Publish Status: FREE
Abstract Title:

Potent protein glycation inhibition of plantagoside in Plantago major seeds.

Abstract Source:

Biomed Res Int. 2014 ;2014:208539. Epub 2014 May 7. PMID: 24895551

Abstract Author(s):

Nobuyasu Matsuura, Tadashi Aradate, Chihiro Kurosaka, Makoto Ubukata, Shiho Kittaka, Yuri Nakaminami, Kanae Gamo, Hiroyuki Kojima, Mitsuharu Ohara

Article Affiliation:

Nobuyasu Matsuura


Plantagoside (5,7,4',5'-tetrahydroxyflavanone-3'-O-glucoside) and its aglycone (5,7,3',4',5'-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation. These results indicate that P. major seeds have potential therapeutic applications in the prevention of diabetic complications.

Study Type : In Vitro Study

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