P. notoginseng may treat cerebrovascular diseases through multiple pharmacological effects. - GreenMedInfo Summary
for Cerebral Ischemia: A Systematic Review.
Am J Chin Med. 2020 ;48(6):1331-1351. Epub 2020 Sep 9. PMID: 32907361
is the most widely used Chinese medicinal herb for the prevention and treatment of ischemic diseases. Its main active ingredients are saponins, including ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1, among others. This review provides an up-to-date overview on the pharmacological roles ofconstituents in cerebral ischemia. The saponins ofinduce a variety of pharmacological effects in the multiscale mechanisms of cerebral ischemic pathophysiology, including anti-inflammatory activity, reduction of oxidative stress, anti-apoptosis, inhibition of amino acid excitotoxicity, reduction of intracellular calcium overload, protection of mitochondria, repairing the blood-brain barrier, and facilitation of cell regeneration. Regarding cell regeneration,not only promotes the proliferation and differentiation of neural stem cells, but also protects neurons, endothelial cells and astrocytes in cerebral ischemia. In conclusion,may treat cerebrovascular diseases through multiple pharmacological effects, and the most critical ones need further investigation.