Abstract Title:

Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics of the liver in rats.

Abstract Source:

Bull Exp Biol Med. 2008 Feb;145(2):263-5. PMID: 19023985

Abstract Author(s):

L A Ermolaeva, T Yu Dubskaya, T I Fomina, T V Vetoshkina, V E Gol'dberg

Article Affiliation:

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.


Single intravenous injection of paclitaxel to rats in a maximum tolerated dose of 4.6 mg/kg was accompanied by permanent structural and functional changes in the liver. The observed changes were typical of nonspecific reactive hepatitis: infiltration with lymphocytes and macrophages, pyknosis, and focal fatty degeneration of hepatocytes. Liver enzyme activity increased in blood plasma.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.