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Abstract Title:

Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice.

Abstract Source:

J Pharm Pharmacol. 2021 Mar 6 ;73(3):338-346. PMID: 33793876

Abstract Author(s):

Ting Wang, Xu Zhou, Ge Kuang, Rong Jiang, Xinyi Guo, Shengwang Wu, Jingyuan Wan, Liangjun Yin

Article Affiliation:

Ting Wang

Abstract:

OBJECTIVES: The role of Paeoniflorin on hepatic fibrosis and the specific mechanisms has not yet been elucidated. Therefore, we explored whether Paeoniflorin exerted protective effects on carbon tetrachloride (CCl4)-induced hepatic fibrosis and the underlying mechanisms.

METHODS: A model of hepatic fibrosis was induced by intraperitoneally injecting with CCl4 (10% 5μl/g) twice a week for 7 weeks. To explore the effects of Paeoniflorin, mice were treated with Paeoniflorin (100 mg/kg) by gavage once a day at 1 week after modeling until they were sacrificed.

KEY FINDINGS: Paeoniflorin remarkably improved liver function and histopathological changes of hepatic tissues in CCl4-induced liver injury. Besides, the serum MAO enzyme activity and hydroxyproline contents were notably decreased following the intervention of Paeoniflorin. The decreased expression of Vimentin,α-SMA, Col1a and Desmin manifested the inhibition of the hepatic stellate cells (HSCs) activation. Interestingly, Paeoniflorin intervention significantly upregulated the expression of heme oxygenase-1, and attenuated the inflammatory cytokines production as well as the CCl4-induced oxidative stressimbalance.

CONCLUSIONS: Paeoniflorin could effectively alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1, and it might be a new effective option for the comprehensive treatment of hepatic fibrosis.

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