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Abstract Title:

Paeonol Ameliorates Abdominal Aortic Aneurysm Progression by the NF-κB Pathway.

Abstract Source:

Ann Vasc Surg. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34411666

Abstract Author(s):

Shuxiao Chen, Kun Luo, Shuai Bian, Jianfeng Chen, Renfeng Qiu, Xuejun Wu, Gang Li

Article Affiliation:

Shuxiao Chen

Abstract:

OBJECTIVE: Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease characterized by localized progressive dilatation. Currently, paeonol has been shown to possess anti-inflammatory and protective cardiovascular properties. Our study aimed to investigate the potential influences of paeonol on AAA progression.

METHODS: Experimental AAAs were created in C57BL/6J mice by intra-aortic infusion of porcine pancreatic elastase, and then intragastrically administered paeonol (20 mg/kg/day) for 14 days. The effects of paeonol on experimental AAA were measured by ultrasound imaging, histopathology, and western blot analyses.

RESULTS: Paeonol treatment limited the enlargement of the aneurysmal diameter and alleviated the depletion of elastic fibers and vascular smooth muscle cells (VSMCs). Furthermore, the infiltration of CD68+ macrophages and CD8+ lymphocytes was obviously attenuated after paeonol administration, along with mural neoangiogenesis. Western blot results showed that paeonol inhibited the expression of matrix metalloproteinase (MMP) and the NF-κB pathway activation.

CONCLUSIONS: Paeonol might prevent experimental AAA progression by inhibiting the NF-κB pathway, which suggests that it is a potential drug for AAA.

Study Type : Animal Study

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Sayer Ji
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