Paeonol assists fluconazole and amphotericin B to inhibit virulence factors and pathogenicity of Candida albicans. - GreenMedInfo Summary

This study aimed to evaluate the mono- and dual- antifungal activities of paeonol (PAE) and fluconazole (FLZ)/amphotericin B (AmB). To this end, the effects of PAE and FLZ/AmB on cell surface hydrophobicity, hydrolase activity, morphological transition were investigatedand in ainfection model. The results showed a relatively high minimum inhibitory concentration (MIC) and sessile MIC (SMIC) of PAE alone. However, compared with the single drug, the combined use of PAE and FLZ/AmB had a potent synergistic potential to inhibit the virulence factors for. The concomitant use of two drugs was consistently more effective than either drug alone for increasing survival rate, decreasing the fungal burden, and alleviating the pathological features ofinfected by the fungus. Taken together, these findings demonstrate the anti-effects of PAE plus FLZ/AmB and their potential to increase the sensitivity ofto FLZ/AmB of PAE.