Abstract Title:

Paeonol assists fluconazole and amphotericin B to inhibit virulence factors and pathogenicity of.

Abstract Source:

Biofouling. 2021 Oct 6:1-16. Epub 2021 Oct 6. PMID: 34615415

Abstract Author(s):

Min Pan, Qirui Wang, Ting Cheng, Daqiang Wu, Tianming Wang, Guiming Yan, Jing Shao

Article Affiliation:

Min Pan


This study aimed to evaluate the mono- and dual- antifungal activities of paeonol (PAE) and fluconazole (FLZ)/amphotericin B (AmB). To this end, the effects of PAE and FLZ/AmB on cell surface hydrophobicity, hydrolase activity, morphological transition were investigatedand in ainfection model. The results showed a relatively high minimum inhibitory concentration (MIC) and sessile MIC (SMIC) of PAE alone. However, compared with the single drug, the combined use of PAE and FLZ/AmB had a potent synergistic potential to inhibit the virulence factors for. The concomitant use of two drugs was consistently more effective than either drug alone for increasing survival rate, decreasing the fungal burden, and alleviating the pathological features ofinfected by the fungus. Taken together, these findings demonstrate the anti-effects of PAE plus FLZ/AmB and their potential to increase the sensitivity ofto FLZ/AmB of PAE.

Study Type : In Vitro Study
Additional Links
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents : CK(494) : AC(306)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.