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Abstract Title:

Paeonol Interferes With Quorum-Sensing inand Modulates Inflammatory Responsesand.

Abstract Source:

Front Immunol. 2022 ;13:896874. Epub 2022 May 24. PMID: 35686124

Abstract Author(s):

Huaqiao Tang, Dan Yang, Ling Zhu, Fei Shi, Gang Ye, Hongrui Guo, Huidan Deng, Ling Zhao, Zhiwen Xu, Yinglun Li

Article Affiliation:

Huaqiao Tang

Abstract:

Developing quorum-sensing (QS) based anti-infection drugs is one of the most powerful strategies to combat multidrug-resistant bacteria. Paeonol has been proven to attenuate the QS-controlled virulence factors ofby down-regulating the transcription of QS signal molecules. This research aimed to assess the anti-virulence activity and mechanism of paeonol againstinfectionand. In this study, paeonol was found to reduce the adhesion and invasion ofto macrophages and resist the cytotoxicity induced by. Paeonol reduced the expression of virulence factors ofby inhibiting QS, thereby reducing the LDH release and damage of-infected macrophages. Paeonol can inhibit bacterial virulence and enhance the ability of macrophages to clear. In addition, paeonol exerts anti-inflammatory activity by reducing the expression of inflammatory cytokines and increasing the production of anti-inflammatory cytokines. Paeonol treatment significantly inhibited the activation of TLR4/MyD88/NF-κB signaling pathway and decreased the inflammation response of-infected macrophages. Paeonol also significantly reduced the ability ofto infect mice and reduced the inflammatory response. These data suggest that paeonol can inhibit the virulence ofand decrease the inflammation response in-infected macrophages and mice, which can decrease the damage induced byinfection and enhance the ability of macrophages to clear bacteria. This study supports the further development of new potential anti-infective drugs based on inhibition of QS and virulence factors.

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