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Abstract Title:

Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora.

Abstract Source:

Bioorg Chem. 2021 Mar 2 ;110:104783. Epub 2021 Mar 2. PMID: 33714021

Abstract Author(s):

Jing-Fang Zhang, Yan-Cheng Li, Yun-Qing Song, Gui-Yang Xia, Huan Xia, Ya-Nan Wang, Gui-Hua Tian, Guang-Bo Ge, Sheng Lin

Article Affiliation:

Jing-Fang Zhang

Abstract:

Paeonone A (1), a unique nonanortriterpenoid, and a new octanortriterpenoid, paeonone B (2), were isolated from the roots of Paeonia lactiflora, together with a known analogue, palbinone (3). Paeonone A (1) is the first example of naturally occurring nonanortriterpenoid with a diketo acid group. Extensive NMR and HRESIMS experiments were applied to identify the structures of 1 and 2, and their absolute configurations were solved by single-crystal X-ray diffraction and ECD data. Biological properties of 1-3 were explored against pancreatic lipase and cancer cell lines.

Study Type : In Vitro Study

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