Abstract Title:

PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.

Abstract Source:

Int J Clin Exp Pathol. 2015 ;8(1):432-40. Epub 2015 Jan 1. PMID: 25755731

Abstract Author(s):

Lei Sun, Zhen He, Jia Ke, Senmao Li, Xianrui Wu, Lei Lian, Xiaowen He, Xiaosheng He, Jiancong Hu, Yifeng Zou, Xiaojian Wu, Ping Lan

Article Affiliation:

Lei Sun


Platelet activating factor (PAF), a potent pro-inflammatory phospholipid, has been found to trigger tumor growth and angiogenesis through its G-protein coupled receptor (PAFR). This study was aimed to investigate the potential role of PAF in azoxymethane (AOM)/dextran sulfate sodium (DSS) induced colitis-associated cancer (CAC), using PAFR antagonist Ginkgolide B (GKB). We found GKB up-regulated serum level of PAF-AH activity. As assessed by disease activity index (DAI), histological injury scores, leukocytes infiltration, and expression of pro-inflammatory cytokines, GKB ameliorated colonic inflammation and decreased tumor number and load in mice. GKB also decreased expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in tumor. These results suggest that PAFR antagonist might be a potential therapeutic strategy for CAC.

Study Type : Animal Study

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