Article Publish Status: FREE
Abstract Title:

Saponins Protect Myocardial Ischemia Reperfusion No-Reflow Through Inhibiting the Activation of NLRP3 Inflammasome via TLR4/MyD88/NF-κB Signaling Pathway.

Abstract Source:

Front Pharmacol. 2020 ;11:607813. Epub 2021 Jan 15. PMID: 33628178

Abstract Author(s):

Ping Yu, Yuangeng Li, Wenwen Fu, Xin Li, Yanzhe Liu, Yaozhen Wang, Xiaofeng Yu, Huali Xu, Dayun Sui

Article Affiliation:

Ping Yu


At present, many patients who undergo reperfusion immediately after percutaneous coronary intervention will undergo microvascular obstruction and reduction in myocardial blood flow. This phenomenon is called"no-reflow (NR),"and there is still no effective therapy for NR. Studies showedsaponins (PQS) have effect on MI/R injury, while the effect and mechanism of PQS on MI/R induced NR are not clear. In this study, we established a MI/R model to investigate whether PQS decrease NR phenomenonsuppression of inflammation. We found that PQS significantly alleviated the symptoms of NR by reducing ischemia, infarction, and NR area; improving cardiac function; preventing pathological morphology changes of myocardium; depressing leukocytes' aggregation and adhesion; and suppressing the excessive inflammation. Further study demonstrated that PQS remarkably inhibited TLR4, MyD88, p-NF-κB, and NLRP3 inflammasome-associated protein, and these effects could be reversed by LPS. These results indicated that PQS may protect NR by inhibiting the activation of NLRP3 inflammasomeTLR4/MyD88/NF-κB signaling pathway in part, suggesting that PQS exist potential in preventing NR induced by MI/R.

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