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Article Publish Status: FREE
Abstract Title:

Particle air pollution and gestational diabetes mellitus in Houston, Texas.

Abstract Source:

Environ Res. 2020 11 ;190:109988. Epub 2020 Jul 25. PMID: 32745750

Abstract Author(s):

Amal Rammah, Kristina W Whitworth, Elaine Symanski

Article Affiliation:

Amal Rammah

Abstract:

BACKGROUND: There is mixed evidence implicating prenatal exposure to particulate matter<2.5μm in aerodynamic diameter (PM) in the risk of gestational diabetes mellitus (GDM) and only one study has examined exposure to PMconstituents, which vary with location because of different emission sources.

METHODS: We conducted a retrospective cohort study of singleton live births in Harris County, Texas from 2008 to 2013. With data from the Texas Commission on Environmental Quality (TCEQ), we spatially interpolated maternal exposures to total and speciated PM, nitrogen dioxide (NO) and ozone (O) over the 12-week preconception period and trimesters 1 and 2. We estimated odds ratios (OR) and 95% confidence intervals (CI) for the association between pre-conception and pregnancy exposures to total and speciated PMand odds of GDM, adjusted for temperature and maternal covariates. We also evaluated confounding from NOand Oexposures in multi-pollutant models.

RESULTS: An interquartile range (IQR) increase in total PMexposure was associated with elevated odds for developing GDM over the preconception (adjusted OR = 1.09, 95% CI: 1.06, 1.12), first trimester (OR = 1.13, 95% CI: 1.10, 1.17) and second trimester (OR = 1.13, 95% CI: 1.09, 1.17) periods. Effect estimates increased with adjustment for NOand O. We observed modest increases in odds of GDM for IQR increases in first trimester ammonium ion PM(OR = 1.03, 95% CI: 1.00, 1.05) and sulfate PM(OR = 1.03, 95% CI: 1.00, 1.05) exposures, as well as preconception Cr PMexposures (OR = 1.05, 95% CI: 1.02, 1.07).

CONCLUSION: Exposures to PM, before and during pregnancy were associated with elevated odds of GDM. Mitigating air pollution exposures may reduce the risk of GDM and its long-term implications for maternal and child health.

Study Type : Human Study

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