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Article Publish Status: FREE
Abstract Title:

Association between coarse particulate matter (PM) and nasopharyngeal carcinoma among Taiwanese men.

Abstract Source:

J Investig Med. 2019 Oct 16. Epub 2019 Oct 16. PMID: 31619486

Abstract Author(s):

Hsu-Chih Huang, Disline Manli Tantoh, Shu-Yi Hsu, Oswald Ndi Nfor, Cheau-Feng Lin Frank, Chia-Chi Lung, Chien-Chang Ho, Chih-Yi Chen, Yung-Po Liaw

Article Affiliation:

Hsu-Chih Huang

Abstract:

The nasopharyngeal tract traps mainly coarse particles in inhaled air. Soluble carcinogenic compounds, endotoxins, and trace metals contained in these particles are potential causes of inflammation and oxidative stress which could enhance carcinogenesis. The aim of this study was to determine the association between coarse particulate matter (PM) and nasopharyngeal cancer (NPC). A total of 521,098 men (355 cases and 520,743 non-cases), aged≥40 years were included in this study. Data were retrieved from the Taiwan Cancer Registry, the Adult Preventive Medical Services Database, and the Air Quality Monitoring Database. PMwas significantly associated with a higher risk of NPC after adjusting for SO, NOx, O, age, body mass index, smoking, alcohol drinking, betel nut chewing, exercise, hypertension, diabetes, and hyperlipidemia. With PM<20.44μg/mas the reference, the ORs and 95% CIs were 1.47; 1.03-2.11, 1.34; 0.94-1.91, and 1.68; 1.16-2.44 for 20.44≤PM<24.08, 24.08≤PM<29.27, and PM≥29.27 μg/m, respectively. PMremained significantly associated with a higher risk of NPC after further adjustments were made for the aforementioned covariates and PMThe ORs; 95% CIs were 1.42; 0.96 to 2.12, 1.41; 0.94 to 2.10, and 1.71; 1.10 to 2.66 for 20.44≤PM<24.08, 24.08≤PM<29.27, and PM≥29.27 μg/m, respectively. In conclusion, PMwas significantly associated with a higher risk of NPC in Taiwanese men.

Study Type : Human Study

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