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Article Publish Status: FREE
Abstract Title:

Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury.

Abstract Source:

Front Cell Dev Biol. 2021 ;9:693533. Epub 2021 Jul 22. PMID: 34368142

Abstract Author(s):

Chongan Huang, Weiqi Zhang, FeiFan Chu, Hao Qian, Yining Wang, Fangzhou Qi, Mengke Ye, Jiaying Zhou, Zhi Lin, ChenLin Dong, Xiangyang Wang, Qingqing Wang, Haiming Jin

Article Affiliation:

Chongan Huang

Abstract:

Spinal cord injury (SCI) is a destructive and complex disorder of the central nervous system (CNS) for which there is no clinical treatment. Blood-spinal cord barrier (BSCB) rupture is a critical event in SCI that aggravates nerve injury. Therefore, maintaining the integrity of the BSCB may be a potential method to treat SCI. Here, we showed that patchouli alcohol (PA) exerts protective effects against SCI. We discovered that PA significantly prevented hyperpermeability of the BSCB by reducing the loss of tight junctions (TJs) and endothelial cells. PA also suppressed endoplasmic reticulum stress and apoptosis. Furthermore, in a rat model of SCI, PA effectively improved neurological deficits. Overall, these results prove that PA exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for SCI treatment.

Study Type : In Vitro Study

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Sayer Ji
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