n/a
Article Publish Status: FREE
Abstract Title:

Unraveling the Novel Protective Effect of Patchouli Alcohol Against-Induced Gastritis: Insights Into the Molecular Mechanismand.

Abstract Source:

Front Pharmacol. 2018 ;9:1347. Epub 2018 Nov 22. PMID: 30524287

Abstract Author(s):

Da-Wei Lian, Yi-Fei Xu, Wen-Kang Ren, Li-Jun Fu, Fang-Jun Chen, Li-Yao Tang, Hui-Ling Zhuang, Hong-Ying Cao, Ping Huang

Article Affiliation:

Da-Wei Lian

Abstract:

Patchouli alcohol (PA), a natural tricyclic sesquiterpene extracted from(Blanco) Benth. (Labiatae), has been found to exhibit anti-and anti-inflammatory properties. In this study, we investigated the protective effect of PA againstinduced gastritisand, and determined the underlying mechanism. In theexperiment, a C57BL/6 mouse model of gastritis was established usingSS1, and treatments with standard triple therapy or 5, 10, and 20 mg/kg PA were performed for 2 weeks. Results indicated that PA effectively attenuated oxidative stress by decreasing contents of intracellular reactive oxygen species (ROS) and malonyldialdehyde (MDA), and increasing levels of non-protein sulfhydryl (NP-SH), catalase and glutathione (GSH)/glutathione disulphide (GSSG). Additionally, treatment with PA significantly attenuated the secretions of interleukin 1 beta (IL-1β), keratinocyte chemoattractant and interleukin 6 (IL-6). PA (20 mg/kg) significantly protected the gastric mucosa from-induced damage. In theexperiment, GES-1 cells were cocultured withNCTC11637 at MOI = 100:1 and treated with different doses of PA (5, 10, and 20μg/ml). Results indicated that PA not only significantly increased the cell viability and decreased cellular lactate dehydrogenase (LDH) leakage, but also markedly elevated the mitochondrial membrane potential and remarkably attenuated GES-1 cellular apoptosis, thereby protecting gastric epithelialcells against injuries caused by. PA also inhibited the secretions of pro-inflammatory factors, such as monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor-α (TNF-α) and IL-6. Furthermore, after PA treatment, the combination of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and cysteine-aspartic proteases 1 (CASPASE-1), the expression levels of NLRP3 inflammasome-related proteins, such as thioredoxin-interacting protein (TXNIP), pro-CASPASE-1, cle-CASPASE-1, and NLRP3 and genes (and) were significantly decreased as compared to the model group. In conclusion, treatment with PA for 2 weeks exhibited highly efficient protective effect against-induced gastritis and related damages. The underlying mechanism might involve antioxidant activity, inhibition of pro-inflammatory factor and regulation of NLRP3 inflammasome function. PA exerted anti-and anti-gastritis effects and thus had the potential to be a promising candidate for treatment of-related diseases.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.