Abstract Title:

Immune responses following cocktails of inactivated measles vaccine and Arachis hypogaea L. (groundnut) or Cocos nucifera L. (coconut) oils adjuvant.

Abstract Source:

Vaccine. 1996 Dec ;14(17-18):1703-6. PMID: 9032902

Abstract Author(s):

N O Eghafona

Article Affiliation:

Department of Microbiology, University of Benin, Nigeria.


Haemagglutination inhibition (HAI), geometric mean titre (GMT) and lymphocyte transformation test (LTT) were measured following inoculation of Erythrocebus patas with inactivated measles vaccine (IMV) and oils of Arachis hypogaea L (GO), Cocos nucifera L (CO), Freund's complete and incomplete adjuvants (FCA, FIA). The GMT of HAI were: GO + IMV = 8.50 +/- 4.15: CO + IMV = 8.08 +/- 4.03; FCA + IMV = 7.67 +/- 4.08. FIA + IMV = 7.08 +/- 4.08 compared with controls of live measles vaccine (LMV) = 7.33 +/- 4.33 and IMV = 4.33 +/- 4.56. The mean stimulation ratio (SR) of lymphocyte transformation data were: GO + IMV = 109 69; CO + IMV = 58.47; FCA + IMV = 55.81. FIA + IMV = 55.48; LMV = 94.73; IMV = 55.64. The results when compared by a two-way multiple pairwise comparison of Tuskey's procedure at alpha = 0.05 showed that HAI antibody titres were not significantly different in all the groups under investigation. The lymphocyte transformation data for GO + IMV and LMV were identical but significantly different from the other groups. The study suggests that the oils under investigation, particularly the GO oil should be considered as an adjuvant with IMV after extensive study in humans; since it stimulated cellular immune response comparable to that of LMV. This is a promising alternative to the use of LMV in the tropical developing countries with poor storage facilities.

Study Type : Human In Vitro

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.