Abstract Title:

Perinatal exposure to bisphenol A modifies the transcriptional regulation of theβ-Casein gene during secretory activation of the rat mammary gland.

Abstract Source:

Mol Cell Endocrinol. 2016 Sep 30. Epub 2016 Aug 30. PMID: 27697584

Abstract Author(s):

Gabriela A Altamirano, Jorge G Ramos, Ayelen L Gomez, Enrique H Luque, Monica Muñoz-de-Toro, Laura Kass

Article Affiliation:

Gabriela A Altamirano


With the aim to analyze whether bisphenol A (BPA) modifiesβ-Casein (β-Cas) synthesis and transcriptional regulation in perinatally exposed animals, here, pregnant F0 rats were orally exposed to 0, 0.6 or 52 μg BPA/kg/day from gestation day 9 until weaning. Then, F1 females were bred and mammary glands were obtained on lactation day 2. Perinatal BPA exposure decreased β-Cas expression without modifying the activation of prolactin receptor. It also decreased the expression of glucocorticoid receptor in BPA52-exposed dams and β1 and α6 integrins as well as dystroglycan in both BPA groups. In addition, BPA exposure altered the expression of histone-modifying enzymes and induced histone modifications and DNA methylation in the promoter, enhancer and exon VII of the β-Cas gene. An impaired crosstalk between the extracellular matrix and lactogenic hormone signaling pathways and epigenetic modifications of the β-Cas gene could be the molecularmechanisms by which BPA decreased β-Cas expression.

Study Type : Animal Study

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