Article Publish Status: FREE
Abstract Title:

Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex.

Abstract Source:

Biomed Environ Sci. 2016 Sep ;29(9):686-689. PMID: 27806752

Abstract Author(s):

Liang Gao, Han Ning Wang, Ling Zhang, Fang Yuan Peng, Yue Jia, Wei Wei, Li Hong Jia

Article Affiliation:

Liang Gao


Rats were exposed to 1 or 10μg/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin (ADP) levels in both female and male offspring rats. Liver adipose triglyceride lipase (Atgl) mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.

Study Type : Animal Study

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