Abstract Title:

Peripheral neuropathy and lipid-lowering therapy.

Abstract Source:

South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841

Abstract Author(s):

P E Ziajka, T Wehmeier

Article Affiliation:

Florida Lipid Associates, Orlando 32806, USA.


We report a case of a peripheral neuropathy induced and exacerbated by several commonly used HMG-CoA reductase inhibitors including lovastatin, simvastatin, pravastatin, and atorvastatin, and the vitamin niacin. A review of the literature shows similar cases with individual lipid-lowering drugs, but this case shows the cross-reactivity of the neuropathic process to different HMG-CoA reductase inhibitors, and it is the first reported case of a peripheral neuropathy exacerbated by the use of niacin.

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