Abstract Title:

Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect.

Abstract Source:

J Agric Food Chem. 2004 Aug 11 ;52(16):5297-302. PMID: 15291511

Abstract Author(s):

Cyril Auger, Peggy Gérain, Florence Laurent-Bichon, Karine Portet, Aurélie Bornet, Bertrand Caporiccio, Gérard Cros, Pierre-Louis Teissédre, Jean-Max Rouanet

Article Affiliation:

Cyril Auger


The aim of this study was to evaluate the antiatherosclerotic effect of commercially available phenolic-rich extracts from grape seeds (ExGrape seeds, EGS; grape seed extract, GSE) and marc (ExGrape total, EGT) in cholesterol-fed hamsters and to investigate possible operating mechanisms. These extracts fed at a moderate dose mimicking two glasses of red wine per meal reduced plasma cholesterol (-11% on average) but did not affect plasma antioxidant capacity of hamsters. The extracts prevented the development of aortic atherosclerosis by 68% (EGS), 63% (EGT), and 34% (GSE). Elsewhere, in an ex vivo experiment using rat aortic rings, EGS (7 microg/mL) induced 77% endothelium-dependent relaxation, whereas EGT and GSE (30 microg/mL) induced 84 and 72%, respectively. These results suggests that phenolic extracts from grape seeds and marc are beneficial in inhibiting atherosclerosis by indirect mechanism(s).

Study Type : Animal Study

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