Phenylethyl cinnamides: a new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos. - GreenMedInfo Summary
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Abstract Title:
Phenylethyl cinnamides: a new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos.
Abstract Source:
Bioorg Med Chem Lett. 2008 Sep 15 ;18(18):4956-8. Epub 2008 Aug 14. PMID: 18760601
Article Affiliation:
Preecha Phuwapraisirisan
Abstract:
A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline, aegelinosides A and B, were isolated from Aegle marmelos leaves as alpha-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline revealed the most potent inhibitory effect against alpha-glucosidase with IC(50) value of 35.8 microM. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus.
Article Published Date : Sep 14, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bael : CK(132) : AC(77)
Diseases : Hypoglycemia : CK(345) : AC(90)
Pharmacological Actions : Alpha-glucosidase inhibitor : CK(274) : AC(284), Hypoglycemic Agents : CK(5366) : AC(1911)
