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Article Publish Status: FREE
Abstract Title:

Phlorofucofuroeckol A from Edible Brown AlgaEnhances Osteoblastogenesis in Bone Marrow-Derived Human Mesenchymal Stem Cells.

Abstract Source:

Mar Drugs. 2019 Sep 21 ;17(10). Epub 2019 Sep 21. PMID: 31546680

Abstract Author(s):

Jung Hwan Oh, Byul-Nim Ahn, Fatih Karadeniz, Jung-Ae Kim, Jung Im Lee, Youngwan Seo, Chang-Suk Kong

Article Affiliation:

Jung Hwan Oh

Abstract:

The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga. The ability of PFF-A to enhance osteoblast differentiation was observed in murine pre-osteoblast cell line MC3T3-E1 and human bone marrow-derived mesenchymal stem cells (huBM-MSCs). Proliferation and alkaline phosphatase (ALP) activity of osteoblasts during differentiation was assayed following PFF-A treatment along extracellular mineralization. In addition, effect of PFF-A on osteoblast maturation pathways such as Runx2 and Smads was analyzed. Treatment of PFF-A was able to enhance the proliferation of differentiating osteoblasts. Also, ALP activity was observed to be increased. Osteoblasts showed increased extracellular mineralization, observed by Alizarin Red staining, following PFF-A treatment. In addition, expression levels of critical proteins in osteoblastogenesis such as ALP, bone morphogenetic protein-2 (BMP-2), osteocalcin andβ-catenin were stimulated after the introduction of PFF-A. In conclusion, PFF-A was suggested to be a potential natural product with osteoblastogenesis enhancing effects which can be utilized against bone-remodeling imbalances and osteoporosis-related complications.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Osteoprotective : CK(971) : AC(351)
Problem Substances : Dioxins : CK(28) : AC(9)

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