Article Publish Status: FREE
Abstract Title:

Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity.

Abstract Source:

Cardiol Res Pract. 2019 ;2019:7395239. Epub 2019 Dec 23. PMID: 31929900

Abstract Author(s):

Yuewen Wang, Xu Chao, Fiaz Ud Din Ahmad, Hailong Shi, Hania Mehboob, Waseem Hassan

Article Affiliation:

Yuewen Wang


Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine the effect ofextract (PDE) on DOX-induced cardiotoxicity and nephrotoxicity. Experimental rats were divided into four groups, receiving normal saline 4 ml/kg, DOX alone, and crude extract of PDE at doses of 1 g/kg and 1.5 g/kg in the presence of DOX, respectively, for 21 days. Cardiac enzymes and serum and urinary sodium and potassium levels were evaluated which were analyzed statistically by using one-way ANOVA. Subsequently, DOX initiatedchanges in the level of cardiac markers CK-MB, LDH, and troponin I, which were notably reversed by PDE. PDE was also effective against serum and urinary sodium and urinary potassium and protected against DOX-induced nephrotoxicity. Groups treated with different doses of PDE showed marked decrease inlevels of cardiac and renal markers. The study concluded that the PDE extract possesses protective effects against DOX-induced cardiotoxicity and nephrotoxicity.

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