Abstract Title:

Photo-induced electron emission from 17beta-estradiol and progesterone and possible biological consequences.

Abstract Source:

J Photochem Photobiol B. 2008 Jul 24 ;92(1):38-41. Epub 2008 Apr 15. PMID: 18499468

Abstract Author(s):

Nikola Getoff, Johannes Hartmann, Johannes C Huber, Ruth Maria Quint

Article Affiliation:

Department of Nutritional Sciences, Section Radiation Biology, The University of Vienna, A-1090 Vienna, Althanstrasse 14, UZAII, Austria. [email protected]

Abstract:

It was established for the first time, that the sexual hormones 17beta-estradiol (17betaE2) and progesterone (PRG) are able to emit electrons from their excited single state in water-ethanol mixtures. The yield of the"solvated electrons"(e(s)(-)) depends on the substrate concentration, the ratio of water-alcohol-mixtures and the temperature. The e(s)(-) yield obtained from 17betaE2 is by two orders of magnitude higher than this of PRG. The possible relationship of the resulting hormone transients from 17betaE2 leading via specific metabolites to breast cancer is discussed.

Study Type : In Vitro Study

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