Abstract Title:

Photobiomodulation therapy combined with radiotherapy in the treatment of triple-negative breast cancer-bearing mice.

Abstract Source:

J Photochem Photobiol B. 2021 May 17 ;220:112215. Epub 2021 May 17. PMID: 34029847

Abstract Author(s):

Camila Ramos Silva, Camila de Almeida Salvego, Maria Elisa Rostelato, Carlos Alberto Zeituni, Martha Simões Ribeiro

Article Affiliation:

Camila Ramos Silva


This work investigated the effect of photobiomodulation therapy (PBM) combined with radiotherapy (RT) on triple-negative breast cancer (TNBC)-bearing mice. Female BALB/c mice received 4 T1 cells into a mammary fat pad. Local RT was performed with a total dose of 60 Gy divided into 4 consecutive sessions of 15 Gy. For PBM, a red laser was used in three different protocols: i-) single exposure delivering 150 J.cm(24 h after the last RT session), and ii-) radiant exposure of 150 J.cmor iii-) fractionated radiant exposure of 37.5 J.cm(after each RT session). Tumor volume, complete blood cell count, clinical condition, metastasis, and survival of animals were monitored during 3 weeks post-RT. Our results demonstrated that regardless of the protocol, PBM arrested the tumor growth, improved the clinical condition, and prevented hemolytic anemia. Besides, although PBM groups have exhibited a high neutrophil:lymphocyte ratio (NLR), they decreased the number of lung metastases and enhanced mouse survival. Worthy of note, PBM should be used along with the RT sessions in higher radiant exposures, since PBM at 150 J.cmper session significantly extended the survival rate. Together, these data suggest PBM could be a potential ally to RT to fight TNBC.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.