Article Publish Status: FREE
Abstract Title:

Photobiomodulation Therapy in Cancer Patients with Mucositis: A Clinical Evaluation.

Abstract Source:

Photobiomodul Photomed Laser Surg. 2019 Mar ;37(3):142-150. Epub 2019 Feb 20. PMID: 31050952

Abstract Author(s):

Sérgio Luiz Pinheiro, Ana Cláudia Bonadiman, Ana Luiza Dos Anjos Borges Lemos, Bruna Maki Annicchino, Bruna Segatti, Daniel Sartorelli Pucca, Priscila Tessaro Dutra, Roberta Mariano de Carvalho E Silva, Frederico Leal

Article Affiliation:

Sérgio Luiz Pinheiro


To evaluate the use of photobiomodulation therapy (PBM-T) in patients undergoing chemotherapy and/or radiotherapy and affected by oral mucositis (OM).Few clinical studies have evaluated PBM-T, particularly in combination with photodynamic therapy (PDT), for the treatment of OM.Thirty-one patients were divided by convenience into two groups. One received PBM-T ( = 17) alone, consisting of low-intensity laser (LIL) irradiation (wavelength 660 nm, continuous mode, spot energy 4 J, energy density 142 J/cm, irradiation time 40 s per spot), once weekly for 4 weeks. The other ( = 14) received a combination of PBM-T and PDT, with curcumin as photosensitizer. Patients were instructed to rinse their mouth with 20 mL of curcumin solution for 5 min. The oral cavity was irradiated with a blue light-emitting diode (power 1200 mV, wavelength 468 nm) for 5 min. LIL was applied as in the PBM-T group. After treatment, OM severity was reassessed. The results were analyzed by the Wilcoxon and Mann-Whitney tests.Both PBM-T alone and PBM-T+PDT yielded significant reductions in OM grade ( < 0.01). PDT+PBM-T resulted in a significantly shorter healing time compared with PBM-T alone ( = 0.0321).Within the parameters of this study, PBM-T+PDT was an effective method to accelerate the OM healing process.

Study Type : Human Study

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